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Congenica Inherited Cancer

Inherited Cancers

While most cancers develop spontaneously, around 5% of cancer diagnoses are linked to certain genetic markers that are passed down generations. Harbouring any of these variations doesn't automatically mean that an individual develops cancer, however, it certainly puts this person at greater risk.

Cancer types typically associated with inherited variants

  • Breast Cancer (BRCA1, BRCA2, PALB2)

  • Ovarian Cancer (BRCA1, BRCA2)

  • Pancreatic Cancer (BRCA1, BRCA2)

  • Prostate Cancer (BRCA1, BRCA2)

  • Li-Fraumeni Syndrome (TP53)

  • Hereditary non polyposis colon cancer/Lynch Syndrome (MLH1, MSH2, MSH6, PMS2)

  • Hamartoma Tumour Syndrome (PTEN)

  • Familial adenomatous polyposis (APC)

  • MUTYH associated polyposis (MUTYH)

  • Peutz Jeghers Syndrome (STK11)

  • Juvenile Polyposis Syndrome (SMAD4, BMPR1A)

  • Von Hippel Lindau Syndrome (VHL)

  • Tuberous sclerosis (TSC1, TSC2)

  • Birt-Hogg-Dube Syndrome (FLCN)

  • Multiple endocrine neoplasia type 1 and 2 (RET)

  • Retinoblastoma (RB1)

  • Familial Atypical Multiple Mole Melanoma Syndrome (CDKN2A)

  • Hereditary papillary cancer (MET, FH)

Identifying causative variants helps patient management, ensures potential tumours are detected as early as possible, provides options for preventative treatments and helps understand the implications for family members.


With our scalable, automated and cost-effective diagnostic platform Congenica is ideally placed to rapidly provide life-changing answers to patients and their families.

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Rapid turnaround time

Automated processes for fast and accurate decision-making supported by machine learning and AI

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Increased diagnostic yield

Increased diagnostic yield through automated variant prioritisation and expertly curated reference databases

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CE-IVD certified

Validated, accurate and secure platform for high confidence in diagnostic outcome

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Ultimate flexibility

From gene panels to whole genomes, SaaS or on premise, we offer ultimate flexibility to support all customer needs

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